Generally, it’s not a good idea to mix this with anything, but there isn’t a ton of research on cannabis mixing with 5-HTP. If you’re curious about this, you may wonder it. There are some people who use cannabis to help with sleeping, depression, and other issues, and they might use this to help with imbalances within the body. 5-HTP is something that’s also combined to help you without the awareness. But there isn’t much trials, so it may not be safe to combine, however, this does differ between person to person on how they experience this, and what happens if taken separately, or together as well.
What is 5-HTP though?
This is something that some people may take for a variety of reasons. It’s a chemical that causes the amino acid tryptophan to form within your body, and it’s used in commercial consumption through the seeds a plant from Africa. This is usually converted in the body into something called serotonin, which is the happy hormone. But this also helps with regulating sleep, mood, and everything else, and it can relieve depression and anxiety symptoms too. Some people take this for a few reasons, which include the following:
- Stimulating the sleeping and eating you do
- Improving your emotional state and helping to evoke positive emotions
- Offering better sleep
- Improving sex drive
- Reduce anxiety in the body
These are great benefits, but you might wonder if it’ll cause issues with weed. Here’s what we’ve got.
Mixing 5-HTP with Weed
Weed is not just a plant that gets you stoned, but there are a ton of chemicals in it, and a variety of different side effects, which can impact you. THC, CBN, CBD, and others mainly make up it. They do get processed within your body in the same group of enzymes that are used to metabolize and also get rid of medications that are there. It’s something that uses the same metabolic pathway as 5-HTP, so it’s something that you may also feel amplified, or in some cases, it may be a lot less.
This is because it creates a synergistic result of this, combining the substances into something dangerous, unpredictable, and something with potentially negative consequences that come with this. Cannabis is something that gets used for medical, and recreational reasons, with 5-HTP being present within the CNS and the brain already, this is something that’s supposedly a supplement, since it does help with the production of serotonin to help with reducing depression and the like.

While there are some studies that have been put out for this, usually a person who has depression takes one or the other. There are a few people that will combine them since it can make it stronger, and it might be for therapeutic or recreational reasons.
There are potential benefits, in that it can cause an increase in dreams, help with sleeping better since melatonin can help with improving the sleepy nature of this. This can also help with balancing out the tiredness that some people feel with marijuana.
Side Effects
The side effects are pain in the abdomen, nausea, allergies, and the like. Some people may have too much serotonin in the body, which causes agitation and seizures, and it might cause psychosis, anxiety, heart rate elevation, nausea, and problems breathing, and vomiting this does potentially exacerbate all of this.

With that said it’s important to be mindful of all of the different aspects of this, and also take all of this into consideration when choosing it too.